Publikationen


2017

Nebel C, Aslanidis A, Rashid K, Langmann T. Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells. Biochem Biophys Res Commun. 2017 Mar 11;484(3):681-686.

Martens TF, Peynshaert K, Nascimento TL, Fattal E, Karlstetter M, Langmann T, Picaud S, Demeester J, De Smedt SC, Remaut K, Braeckmans K. Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy. Eur J Pharm Sci. 2017 Feb 20.

Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H. Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina. EMBO Mol Med. 2017 Feb;9(2):154-166.

Wolf A, Aslanidis A, Langmann T. Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression. Biochem Biophys Res Commun. 2017 Jan 29;483(1):346-351.

Schick T, Steinhauer M, Aslanidis A, Altay L, Karlstetter M, Langmann T, Kirschfink M, Fauser S. Local complement activation in aqueous humor in patients with age-related macular degeneration. Eye (Lond). 2017 Jan 27.

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C. Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation. 2017 Jan 5;14(1):4.

2016

Scholz R, Langmann T. Gut flora connects obesity with pathological angiogenesis in the eye. EMBO Mol Med. 2016 Dec 1;8(12):1361-1363.

Coppieters F, Ascari G, Dannhausen K, Nikopoulos K, Peelman F, Karlstetter M, Xu M, Brachet C, Meunier I, Tsilimbaris MK, Tsika C, Blazaki SV, Vergult S, Farinelli P, Van Laethem T, Bauwens M, De Bruyne M, Chen R, Langmann T, Sui R, Meire F, Rivolta C, Hamel CP, Leroy BP, De Baere E. Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination. Am J Hum Genet. 2016 Aug 4;99(2):470-80.

Altay L, Scholz P, Schick T, Felsch M, Hoyng CB, den Hollander AI, Langmann T, Fauser S. Association of Hyperreflective Foci Present in Early Forms of Age-Related Macular Degeneration With Known Age-Related Macular Degeneration Risk Polymorphisms. Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4315-20.

Lückoff A, Caramoy A, Scholz R, Prinz M, Kalinke U, Langmann T. Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization. EMBO Mol Med. 2016 Jun 1;8(6):670-8.

Zeilbeck LF, Müller BB, Leopold SA, Senturk B, Langmann T, Tamm ER, Ohlmann A. Norrin mediates angiogenic properties via the induction of insulin-like growth factor-1. Exp Eye Res. 2016 Apr;145:317-26.

Van Schil K, Karlstetter M, Aslanidis A, Dannhausen K, Azam M, Qamar R, Leroy BP, Depasse F, Langmann T, De Baere E. Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7. Sci Rep. 2016 Feb 18;6:21307.

Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, Burdon KP, Hebbring SJ, Wen C, Gorski M, Kim IK, Cho D, Zack D, Souied E, Scholl HP, Bala E, Lee KE, Hunter DJ, Sardell RJ, Mitchell P, Merriam JE, Cipriani V, Hoffman JD, Schick T, Lechanteur YT, Guymer RH, Johnson MP, Jiang Y, Stanton CM, Buitendijk GH, Zhan X, Kwong AM, Boleda A, Brooks M, Gieser L, Ratnapriya R, Branham KE, Foerster JR, Heckenlively JR, Othman MI, Vote BJ, Liang HH, Souzeau E, McAllister IL, Isaacs T, Hall J, Lake S, Mackey DA, Constable IJ, Craig JE, Kitchner TE, Yang Z, Su Z, Luo H, Chen D, Ouyang H, Flagg K, Lin D, Mao G, Ferreyra H, Stark K, von Strachwitz CN, Wolf A, Brandl C, Rudolph G, Olden M, Morrison MA, Morgan DJ, Schu M, Ahn J, Silvestri G, Tsironi EE, Park KH, Farrer LA, Orlin A, Brucker A, Li M, Curcio CA, Mohand-Saïd S, Sahel JA, Audo I, Benchaboune M, Cree AJ, Rennie CA, Goverdhan SV, Grunin M, Hagbi-Levi S, Campochiaro P, Katsanis N, Holz FG, Blond F, Blanché H, Deleuze JF, Igo RP Jr, Truitt B, Peachey NS, Meuer SM, Myers CE, Moore EL, Klein R, Hauser MA, Postel EA, Courtenay MD, Schwartz SG, Kovach JL, Scott WK, Liew G, Tan AG, Gopinath B, Merriam JC, Smith RT, Khan JC, Shahid H, Moore AT, McGrath JA, Laux R, Brantley MA Jr, Agarwal A, Ersoy L, Caramoy A, Langmann T, Saksens NT, de Jong EK, Hoyng CB, Cain MS, Richardson AJ, Martin TM, Blangero J, Weeks DE, Dhillon B, van Duijn CM, Doheny KF, Romm J, Klaver CC, Hayward C, Gorin MB, Klein ML, Baird PN, den Hollander AI, Fauser S, Yates JR, Allikmets R, Wang JJ, Schaumberg DA, Klein BE, Hagstrom SA, Chowers I, Lotery AJ, Léveillard T, Zhang K, Brilliant MH, Hewitt AW, Swaroop A, Chew EY, Pericak-Vance MA, DeAngelis M, Stambolian D, Haines JL, Iyengar SK, Weber BH, Abecasis GR, Heid IM. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet. 2016 Feb;48(2):134-43.

2015

Scholz R, Sobotka M, Caramoy A, Stempfl T, Moehle C, Langmann T. Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation. 2015 Nov 17;12:209.

Scholz R, Caramoy A, Bhuckory MB, Rashid K, Chen M, Xu H, Grimm C, Langmann T. Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration. J Neuroinflammation. 2015 Nov 2;12(1):201.

Langmann T. Intracellular Toll-Like Receptors Help Retinal Microglia Sense Corneal Infections. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7387.

Dannhausen K, Karlstetter M, Caramoy A, Volz C, Jägle H, Liebisch G, Utermöhlen O, Langmann T. Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function. Biochem Biophys Res Commun. 2015 Aug 21;464(2):434-40.

Aslanidis A, Karlstetter M, Scholz R, Fauser S, Neumann H, Fried C, Pietsch M, Langmann T. Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia. J Neuroinflammation. 2015 Apr 19;12:77.

Van Schil K, Meire F, Karlstetter M, Bauwens M, Verdin H, Coppieters F, Scheiffert E, Van Nechel C, Langmann T, Deconinck N, De Baere E. Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion. Genet Med. 2015 Apr;17(4):291-9.

Karlstetter M, Scholz R, Rutar M, Wong WT, Provis JM, Langmann T. Retinal microglia: just bystander or target for therapy? Prog Retin Eye Res. 2015 Mar;45:30-57.

Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, Holtman IR, Wang X, Eggen BJ, Boddeke HW, Hambardzumyan D, Wolf SA, Kettenmann H. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS One. 2015 Feb 6;10(2):e0116644.

2014

Karlstetter M, Sorusch N, Caramoy A, Dannhausen K, Aslanidis A, Fauser S, Boesl MR, Nagel-Wolfrum K, Tamm ER, Jagle H, Stoehr H, Wolfrum U, Langmann T. Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration. Hum Mol Genet. 2014 Oct 1;23(19):5197-210.

Van Schil K, Meire F, Karlstetter M, Bauwens M, Verdin H, Coppieters F, Scheiffert E, Van Nechel C, Langmann T, Deconinck N, De Baere E. Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion. Genet Med. 2014 Aug 14.

Ersoy L, Ristau T, Hahn M, Karlstetter M, Langmann T, Draege K, Caramoy A, den Hollander AI, Fauser S. Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older. Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1842-7.

Langmann T, Ueffing M, Kirchhof B, Holz FG, Pauleikhoff D. [In Process Citation]. Klin Monbl Augenheilkd. 2014 Mar;231(3):266-8.

Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, Neumann H, Weber BH, Rupprecht R, Langmann T. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014 Jan 8;11:3.

Volz C, Mirza M, Langmann T, Jagle H. Retinal function in aging homozygous Cln3 (Δex7/8) knock-in mice. Adv Exp Med Biol. 2014;801:495-501.

Karlstetter M, Langmann T. Microglia in the aging retina. Adv Exp Med Biol. 2014;801:207-12.
Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T. RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). Adv Exp Med Biol. 2014;801:31-41.

2013

Mirza M, Volz C, Karlstetter M, Langiu M, Somogyi A, Ruonala MO, Tamm ER, Jagle H, Langmann T. Progressive Retinal Degeneration and Glial Activation in the CLN6 (nclf) Mouse Model of Neuronal Ceroid Lipofuscinosis: A Beneficial Effect of DHA and Curcumin Supplementation. PLoS One. 2013 Oct
4;8(10):e75963.

Langmann T. Class A scavenger receptors shed light on immune cell recruitment and CNV. Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):5971. Zollbrecht C, Grassl M, Fenk S, Haecherl R, Hubauer U, Reinhard W, Esslinger UB, Ebert S, Langmann T, Stark K, Hengstenberg C. Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus. Atherosclerosis. 2013 Apr;227(2):244-9.

Groh J, Kaehl TG, Ip CW, Nelvagal HR, Sri S, Duckett S, Mirza M, Langmann T, Cooper JD, Martini R. Immune cells perturb axons and impair neuronal survival in  a mouse model of infantile neuronal ceroid lipofuscinosis. Brain. 2013 Apr;136(Pt 4):1083-101.

Hlawatsch J, Karlstetter M, Aslanidis A, Lueckoff A, Walczak Y, Plank M, Boeck J, Langmann T. Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina. PLoS One. 2013;8(4):e60633.

2012

Zach F, Grassmann F, Langmann T, Sorusch N, Wolfrum U, Stöhr H. The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association. Hum Mol Genet. 2012 Jul 12.

Groesser L, Herschberger E, Ruetten A, Ruivenkamp C, Lopriore E, Zutt M, Langmann T, Singer S, Klingseisen L, Schneider-Brachert W, Toll A, Real FX, Landthaler M, Hafner C. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat Genet. 2012 Jun 10;44(7):783-7.

Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Correction: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation. 2012 Jun 6;9:118.

Karlstetter M, Langmann T. [Immune mechanisms in retinal degeneration]. Klin Monbl Augenheilkd. 2012 Mar;229(3):221-6.

Ebert S, Walczak Y, Remé C, Langmann T. Microglial activation and
transcriptomic changes in the blue light-exposed mouse retina. Adv Exp Med Biol. 2012;723:619-32.

2011

Karlstetter M, Lippe E, Walczak Y, Moehle C, Aslanidis A, Mirza M, Langmann T. Curcumin is a potent modulator of microglial gene expression and migration. J Neuroinflammation. 2011 Sep 29;8:125.

Kraus D, Karlstetter M, Walczak Y, Hilfinger D, Langmann T, Weber BH. Retinal expression of the X-linked juvenile retinoschisis (RS1) gene is controlled by an upstream CpG island and two opposing CRX-bound regions. Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):245-54.

Friedrich U, Stöhr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, Weber BH. The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis. Hum Mol Genet. 2011 Mar 15;20(6):1132-42.

2010

Schild AM, Rosentreter A, Hellmich M, Lappa A, Dinslage S, Dietlein TS. Effect of a capsular tension ring on refractive outcomes in eyes with high myopia. J Cataract Refract Surg. 2010 Dec;36(12):2087-93.

Kirchhof B. Farewell. Graefes Arch Clin Exp Ophthalmol. 2010 Dec;248(12):1691 Corbo JC, Lawrence KA, Karlstetter M, Myers CA, Abdelaziz M, Dirkes W, Weigelt K, Seifert M, Benes V, Fritsche LG, Weber BH, Langmann T. CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors. Genome Res. 2010 Nov;20(11):1512-25.

Calabrese S, Wenkel H, Rummelt C, Kruse F, Cursiefen C. [Histopathology of retrocorneal membranes after keratoplasty]. Klin Monbl Augenheilkd. 2010 Oct;227(10):815-8.

Karlstetter M, Walczak Y, Weigelt K, Ebert S, Van den Brulle J, Schwer H, Fuchshofer R, Langmann T. The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response. J Immunol. 2010 Sep 15;185(6):3379-90.

Langmann T, Di Gioia SA, Rau I, Stöhr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M, Arsenijevic Y, Weber BH, Gal A, Rivolta C. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet. 2010 Sep 10;87(3):376-81.

Langmann T, Rehli M. Immunobiology. Editorial.Immunobiology. 2010 Sep-Oct;215(9-10):673. Karlstetter M, Ebert S, Langmann T. Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology. 2010 Sep-Oct;215(9-10):685-91. Caramoy A, Dahlke C, Kirchhof B, Liakopoulos S. [A 34-year-old patient with retinal vascular abnormality as a coincidental finding]. Ophthalmologe. 2010 Sep;107(9):852-4.

Rosentreter A, Schild AM, Jordan JF, Krieglstein GK, Dietlein TS. A prospective randomised trial of trabeculectomy using mitomycin C vs an ologen implant in open angle glaucoma. Eye (Lond). 2010 Sep;24(9):1449-57.

Rosentreter A, Mellein AC, Konen WW, Dietlein TS. Capsule excision and Ologen implantation for revision after glaucoma drainage device surgery. Graefes Arch Clin Exp Ophthalmol. 2010 Sep;248(9):1319-24.

Heindl LM, Hofmann TN, Schrödl F, Holbach LM, Kruse FE, Cursiefen C. Intraocular lymphatics in ciliary body melanomas with extraocular extension: functional for lymphatic spread? Arch Ophthalmol. 2010 Aug;128(8):1001-8.

Caramoy A, Liakopoulos S, Menrath E, Kirchhof B. Autologous translocation of choroid and retinal pigment epithelium in geographic atrophy: long-term functional and anatomical outcome. Br J Ophthalmol. 2010 Aug;94(8):1040-4.

Rosentreter A, Schild AM, Wedemeyer I, Dietlein TS. [Epithelial downgrowth 48 years after penetrating eye trauma]. Ophthalmologe. 2010 Aug;107(8):753-6.

Schröder S, Caramoy A, Prinz B, Kirchhof B, Fauser S. [Unexplained loss of visual acuity in a 22-year-old woman]. Ophthalmologe. 2010 Jul;107(7):663-6.

Regenfuss B, Onderka J, Bock F, Hos D, Maruyama K, Cursiefen C. Genetic heterogeneity of lymphangiogenesis in different mouse strains. Am J Pathol. 2010 Jul;177(1):501-10.

Bachmann B, Taylor RS, Cursiefen C. Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis. Ophthalmology.2010 Jul;117(7):1300-5.e7.

Bachmann BO, Laaser K, Cursiefen C, Kruse FE. A method to confirm correct orientation of descemet membrane during descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2010 Jun;149(6):922-925.e2.

Heindl LM, Kruse FE, Cursiefen C. [Complications after posterior lamellar keratoplasty (DSAEK): prevention, detection and treatment]. Klin Monbl Augenheilkd. 2010 Jun;227(6):478-82.

Sekundo W, Droutsas K, Cursiefen C. [Operative techniques for surgical treatment of primary and recurrent pterygia]. Ophthalmologe. 2010 Jun;107(6):525-8. Heindl LM, Cursiefen C. [Pterygium. Etiology, clinical aspects and novel adjuvant therapies]. Ophthalmologe.2010 Jun;107(6):517-20, 522-4.

Lamparter J, Kottler U, Cursiefen C, Pfeiffer N, Pitz S. [Morbus Morbihan : A rare cause of edematous swelling of the eyelids]. Ophthalmologe. 2010 Jun;107(6):553-7.

Kirchhof B. [Advantages and disadvantages of heavy silicone oil]. Ophthalmologe. 2010 Jun;107(6):566, 568-70. Caramoy A, Kirchhof B, Fauser S. [Unilateral metamorphopsia of a young woman]. Ophthalmologe. 2010 May;107(5):468-70.

Caramoy A, Schröder S, Fauser S, Kirchhof B. In vitro emulsification assessment of new silicone oils. Br J Ophthalmol. 2010 Apr;94(4):509-12.

Cursiefen C, Kruse FE. [DMEK: Descemet membrane endothelial keratoplasty]. Ophthalmologe. 2010 Apr;107(4):370-6.

Review. Heindl LM, Hofmann-Rummelt C, Adler W, Holbach LM, Naumann GO, Kruse FE, Cursiefen C. Tumor-associated lymphangiogenesis in the development of conjunctival squamous cell carcinoma. Ophthalmology. 2010 Apr;117(4):649-58.

Preclik A, Langenbucher A, Seitz B, Cursiefen C. [Long-term outcome after penetrating keratoplasty for keratoconus--impact of preoperative corneal curvature and best corrected visual acuity on the functional results]. Klin Monbl Augenheilkd.2010 Mar;227(3):199-207.

Heindl LM, Hofmann TN, Adler W, Knorr HL, Holbach LM, Naumann GO, Kruse FE, Cursiefen C. Intraocular tumor-associated lymphangiogenesis a novel prognostic factor for ciliary body melanomas with extraocular extension? Ophthalmology. 2010 Feb;117(2):334-42.

Jacobi C, Cursiefen C. [Ophthalmological complications in Sjögren's syndrome]. Z Rheumatol. 2010 Feb;69(1):32-40. Review.

Ugocsai P, Hohenstatt A, Paragh G, Liebisch G, Langmann T, Wolf Z, Weiss T, Groitl P, Dobner T, Kasprzak P, Göbölös L, Falkert A, Seelbach-Goebel B, Gellhaus A, Winterhager E, Schmidt M, Semenza GL, Schmitz G. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages. Int J Biochem Cell Biol. 2010 Feb;42(2):241-52.

Joussen AM, Wong D, Walter P, Kirchhof B, Dreyhaupt J, Bauer C, Munzinger J, Unnebrink K, Freiberger A, Seibert-Grafe M, Victor N; MARAN study group. Surgical management of subfoveal choroidal neovascular membranes in age-related macular degeneration by macular relocation: experiences of an early-stopped randomised clinical trial (MARAN Study). Eye (Lond). 2010 Feb;24(2):284-9.

Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R, Langmann T. Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation. 2010 Jan 14;7:3.

Rosentreter A, Dinslage S, Krieglstein GK, Dietlein TS. Intra-individual comparison after combined phaco-trabecular aspiration in pairs of pseudoexfoliative eyes. Graefes Arch Clin Exp Ophthalmol. 2010 Jan;248(1):79-83.

Dietrich T, Bock F, Yuen D, Hos D, Bachmann BO, Zahn G, Wiegand S, Chen L, Cursiefen C. Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation. J Immunol. 2010 Jan 15;184(2):535-9.

Heindl LM, Cursiefen C. [Retained Descemet's membrane after penetrating keratoplasty for macular corneal dystrophy]. Ophthalmologe. 2010 Jan;107(1):55-9.

German. Neubauer AS, Liakopoulos S, van Meurs JC, Kirchhof B. Cost-effectiveness of autologous retinal pigment epithelium and choroid translocation in neovascular AMD. Int J Ophthalmol. 2010;3(3):228-33.

2009

Zimmermann P, Dietrich T, Bock F, Horn FK, Hofmann-Rummelt C, Kruse FE, Cursiefen C. Tumour-associated lymphangiogenesis in conjunctival malignant melanoma. Br J Ophthalmol. 2009 Nov;93(11):1529-34.

Lappas A, Foerster AM, Kirchhof B. Use of heavy silicone oil (Densiron-68) in the treatment of persistent macular holes. Acta Ophthalmol. 2009 Nov;87(8):866-70.

Koenig Y, Bock F, Horn F, Kruse F, Straub K, Cursiefen C. Short- and long-term safety profile and efficacy of topical bevacizumab (Avastin) eye drops against corneal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2009 Oct;247(10):1375-82.

Cursiefen C, Kruse FE; Erlanger DSAEK Gruppe. [Descemet's stripping automated endothelial keratoplasty (DSAEK)]. Ophthalmologe. 2009 Oct;106(10):939-52; quiz 953. Review.

Caramoy A, Fauser S, Kirchhof B, Liakopoulos S. [A case report of two patients with pseudophakia-associated macular edema: can OCT replace fluorescein angiography?]. Klin Monbl Augenheilkd. 2009 Oct;226(10):849-51.

Fricke J, Neugebauer A. [Bilateral modified Hummelsheim procedure in severe bilateral abduction deficiency]. Klin Monbl Augenheilkd. 2009 Oct;226(10):818-21.

Ebert S, Weigelt K, Walczak Y, Drobnik W, Mauerer R, Hume DA, Weber BH, Langmann T. Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. J Neurochem.2009 Sep;110(6):1863-75.

Dietlein TS, Hermann MM, Jordan JF. The medical and surgical treatment of glaucoma. Dtsch Arztebl Int. 2009 Sep;106(37):597-605; quiz 606.

Caramoy A, Lappas A, Fauser S, Kirchhof B. [Central scotoma and blurred vision in a patient with Crohn's disease]. Ophthalmologe. 2009 Sep;106(9):836-8.

Cursiefen C, Bock F, Horn FK, Kruse FE, Seitz B, Borderie V, Früh B, Thiel MA, Wilhelm F, Geudelin B, Descohand I, Steuhl KP, Hahn A, Meller D. GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial. Ophthalmology.2009 Sep;116(9):1630-7.

Bachmann BO, Luetjen-Drecoll E, Bock F, Wiegand SJ, Hos D, Dana R, Kruse FE, Cursiefen C. Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularisation. Br J Ophthalmol. 2009 Aug;93(8):1075-80.

Lutter D, Langmann T, Ugocsai P, Moehle C, Seibold E, Splettstoesser WD, Gruber P, Lang EW, Schmitz G. Analyzing time-dependent microarray data using independent component analysis derived expression modes from human macrophages infected with F. tularensis holartica. J Biomed Inform. 2009 Aug;42(4):605-11.

Hendig D, Langmann T, Zarbock R, Schmitz G, Kleesiek K, Götting C. Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line. Mol Cell Biochem. 2009 Aug;328(1-2):85-92.

Gnewuch C, Liebisch G, Langmann T, Dieplinger B, Mueller T, Haltmayer M, Dieplinger H, Zahn A, Stremmel W, Rogler G, Schmitz G. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol.2009 Jul 7;15(25):3134-41.

Pogorelov P, Cursiefen C, Bachmann BO, Kruse FE. Changes in donor corneal lenticule thickness after Descemet's stripping automated endothelial keratoplasty (DSAEK) with organ-cultured corneas.Br J Ophthalmol.2009 Jun;93(6):825-9.

Bock F, Onderka J, Rummelt C, Dietrich T, Bachmann B, Kruse FE, Schlötzer-Schrehardt U, Cursiefen C. Safety profile of topical VEGF neutralization at the cornea. Invest Ophthalmol Vis Sci. 2009 May;50(5):2095-102.

Heindl LM, Hofmann TN, Knorr HL, Rummelt C, Schrödl F, Schlötzer-Schrehardt U, Holbach LM, Naumann GO, Kruse FE, Cursiefen C. Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension. Invest Ophthalmol Vis Sci. 2009 May;50(5):1988-95.

Cursiefen C. [Bevacizumab goes anterior: antiangiogenic therapy at cornea and conjunctiva]. Ophthalmologe. 2009 May;106(5):397-8.

Regenfuss B, Bock F, Bachmann B, König Y, Hos D, Parthasarathy A, Cursiefen C. [Topical inhibition of angiogenesis at the cornea.Safety and efficacy]. Ophthalmologe. 2009 May;106(5):399-406. Review.

Dietlein TS.[Normal pressure glaucoma--a practice-oriented overview].Klin Monbl Augenheilkd. 2009 May;226(5):R75-84; quiz R85-8.

Nguyen NX, Martus P, Seitz B, Cursiefen C. Atopic dermatitis as a risk factor for graft rejection following normal-risk keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2009 Apr;247(4):573-4.

Weigelt K, Lichtinger M, Rehli M, Langmann T. Transcriptomic profiling identifies a PU.1 regulatory network in macrophages. Biochem Biophys Res Commun. 2009 Mar 6;380(2):308-12.

Pollhammer M, Cursiefen C. Bacterial keratitis early after corneal crosslinking with riboflavin and ultraviolet-A. J Cataract Refract Surg. 2009 Mar;35(3):588-9.

Cursiefen C. [Corneal crosslinking: "Safe and effective"?]. Ophthalmologe. 2009 Feb;106(2):164-5; author reply 165-6.

Dietlein TS, Schild A, Rosentreter A, Jordan JF, Krieglstein GK. [Trabecular meshwork bypass surgery for glaucoma]. Ophthalmologe. 2009 Feb;106(2):161-3. Review.

Mauerer R, Ebert S, Langmann T. High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages. Exp Mol Med. 2009 Feb 28;41(2):126-32.

Stoecker K, Weigelt K, Ebert S, Karlstetter M, Walczak Y, Langmann T. Induction of STAP-1 promotes neurotoxic activation of microglia. Biochem Biophys Res Commun. 2009 Jan 30;379(1):121-6.

Joussen AM, Lux A, Kirchhof B. Shifting of the proliferative vitreoretinopathy milieu after tamponade with heavy silicone oil in eyes prone to proliferative vitreoretinopathy and bleeding. Br J Ophthalmol. 2009 Jan;93(1):128-9.

Mauerer R, Walczak Y, Langmann T. Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays. Methods Mol Biol. 2009;580:187-201

Langmann T, Ebert S, Walczak Y, Weigelt K, Ehrengruber MU, Stiewe T, Weber BH. Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo. Neuromolecular Med. 2009;11(2):87-96.

2008

Dietlein TS, Jordan JF, Lüke C, Schild A, Dinslage S, Krieglstein GK. Self-application of single-use eyedrop containers in an elderly population: comparisons with standard eyedrop bottle and with younger patients. Acta Ophthalmol. 2008 Dec;86(8):856-9.

Dietlein TS, Jordan J, Lueke C, Krieglstein GK. Modern concepts in antiglaucomatous implant surgery. Graefes Arch Clin Exp Ophthalmol.2008 Dec;246(12):1653-64.

Hendig D, Langmann T, Kocken S, Zarbock R, Szliska C, Schmitz G, Kleesiek K, Götting C. Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis. Lab Invest. 2008 Dec;88(12):1303-15.

Paragh G, Schling P, Ugocsai P, Kel AE, Liebisch G, Heimerl S, Moehle C, Schiemann Y, Wegmann M, Farwick M, Wikonkál NM, Mandl J, Langmann T, Schmitz G. Novel sphingolipid derivatives promote keratinocyte differentiation. Exp Dermatol. 2008 Dec;17(12):1004-16.

Schroedl F, Brehmer A, Neuhuber WL, Kruse FE, May CA, Cursiefen C. The normal human choroid is endowed with a significant number of lymphatic vessel endothelial hyaluronate receptor 1 (LYVE-1)-positive macrophages. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5222-9.

Bock F, Onderka J, Hos D, Horn F, Martus P, Cursiefen C. Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts. Exp Eye Res. 2008 Nov;87(5):462-70.

Hos D, Bachmann B, Bock F, Onderka J, Cursiefen C. Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis. Exp Eye Res. 2008 Nov;87(5):427-32.

Dietrich T, Weisbach V, Seitz B, Jacobi C, Kruse FE, Eckstein R, Cursiefen C. [Manufacture of autologous serum eye drops for out-patient therapy : cooperation between ophthalmic clinic and transfusion medicine department]. Ophthalmologe. 2008 Nov;105(11):1036-8, 1040-2.

Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH. CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene. Nucleic Acids Res. 2008 Nov;36(20):6523-34.

Florian C, Langmann T, Weber BH, Morsczeck C. Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells. Biochem Biophys Res Commun. 2008 Sep 19;374(2):187-91.

Van den Brulle J, Fischer M, Langmann T, Horn G, Waldmann T, Arnold S, Fuhrmann M, Schatz O, O'Connell T, O'Connell D, Auckenthaler A, Schwer H. A novel solid phase technology for high-throughput gene synthesis. Biotechniques. 2008 Sep;45(3):340-3.

Ebert S, Schoeberl T, Walczak Y, Stoecker K, Stempfl T, Moehle C, Weber BH, Langmann T. Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype. J Leukoc Biol. 2008 Sep;84(3):736-40.

Weigelt K, Moehle C, Stempfl T, Weber B, Langmann T. An integrated workflow for analysis of ChIP-chip data. Biotechniques. 2008 Aug;45(2):131-2, 134, 136 passim.

Lüke C, Dietlein TS, Lüke M, Konen W, Krieglstein GK. A prospective trial of phaco-trabeculotomy combined with deep sclerectomy versus phaco-trabeculectomy. Graefes Arch Clin Exp Ophthalmol. 2008 Aug;246(8):1163-8.

Heussen FM, Fawzy NF, Joeres S, Lux A, Maaijwee K, Meurs JC, Kirchhof B, Joussen AM. Autologous translocation of the choroid and RPE in age-related macular degeneration: 1-year follow-up in 30 patients and recommendations for patient selection. Eye (Lond). 2008 Jun;22(6):799-807.

Fricke J, Neugebauer A. [Basic principles of eye muscle surgery]. Klin Monbl Augenheilkd. 2008 Jun;225(6):R87-97; quiz R98-9.

Foerster CG, Cursiefen C, Kruse FE. Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody). Cornea. 2008 Jun;27(5):612-4.

Bachmann BO, Pogorelov P, Kruse FE, Cursiefen C. [Patient satisfaction after posterior lamellar keratoplasty (DSAEK)]. Klin Monbl Augenheilkd. 2008 Jun;225(6):577-81.

Joeres S, Llacer H, Heussen FM, Weiss C, Kirchhof B, Joussen AM. Optical coherence tomography on autologous translocation of choroid and retinal pigment epithelium in age-related macular degeneration. Eye (Lond). 2008 Jun;22(6):782-9.

Hos D, Bock F, Dietrich T, Onderka J, Kruse FE, Thierauch KH, Cursiefen C. Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation. Invest Ophthalmol Vis Sci. 2008 May;49(5):1836-42.

Heindl LM, Hofmann-Rummelt C, Schlötzer-Schrehardt U, Kruse FE, Cursiefen C. Histologic analysis of descemet stripping in posterior lamellar keratoplasty. Arch Ophthalmol.2008 Apr;126(4):461-4.

Maaijwee K, Joussen AM, Kirchhof B, van Meurs JC. Retinal pigment epithelium (RPE)-choroid graft translocation in the treatment of an RPE tear: preliminary results. Br J Ophthalmol. 2008 Apr;92(4):526-9.

Shi X, Semkova I, Kociok N, Gavranic C, Becker M, Joussen AM, Kirchhof B. [Effect of anti-TNF-alpha on laser-induced choroidal neovascularization]. Zhonghua Yan Ke Za Zhi. 2008 Mar;44(3):200-6.

Förster CG, Cursiefen C, Kruse FE. [Topical application of EGF for the therapy of persisting corneal erosion under cetuximab treatment]. Ophthalmologe. 2008 Mar;105(3):269-73.

Welsandt G, Fries JW, Konen W, Roters S. [Exophthalmus after orbital haemangiopericytoma removal 18 years ago]. Ophthalmologe.2008 Mar;105(3):274-7.

Milenkovic VM, Langmann T, Schreiber R, Kunzelmann K, Weber BH. Molecular evolution and functional divergence of the bestrophin protein family. BMC Evol Biol. 2008 Feb 28;8:72.

Dietlein TS, Jordan JF, Schild A, Konen W, Jünemann A, Lüke C, Krieglstein GK. Combined cataract-glaucoma surgery using the intracanalicular Eyepass glaucoma implant: first clinical results of a prospective pilot study. J Cataract Refract Surg. 2008 Feb;34(2):247-52.

Bock F, König Y, Kruse F, Baier M, Cursiefen C. Bevacizumab (Avastin) eye drops inhibit corneal neovascularization. Graefes Arch Clin Exp Ophthalmol. 2008 Feb;246(2):281-4.

Cursiefen C, Kruse FE. [Descemet's stripping with automated endothelial keratoplasty (DSAEK)]. Ophthalmologe. 2008 Feb;105(2):183-90, 192. Review.

Bachmann BO, Bock F, Wiegand SJ, Maruyama K, Dana MR, Kruse FE, Luetjen-Drecoll E, Cursiefen C. Promotion of graft survival by vascular endothelial growth factor a neutralization after high-risk corneal transplantation. Arch Ophthalmol. 2008 Jan;126(1):71-7.

Kruse FE, Cursiefen C. Surgery of the cornea: corneal, limbal stem cell and amniotic membrane transplantation. Dev Ophthalmol. 2008;41:159-70. Review.

Bock F, Onderka J, Dietrich T, Bachmann B, Pytowski B, Cursiefen C. Blockade of VEGFR3-signalling specifically inhibits lymphangiogenesis in inflammatory corneal neovascularisation. Graefes Arch Clin Exp Ophthalmol. 2008 Jan;246(1):115-9.

Bartz-Schmidt U, Szurman P, Wong D, Kirchhof B. [New developments in retinal detachment surgery]. Ophthalmologe. 2008 Jan;105(1):27-36. Review.

Regenfuss B, Bock F, Parthasarathy A, Cursiefen C. Corneal (lymph)angiogenesis--from bedside to bench and back: a tribute to Judah Folkman. Lymphat Res Biol. 2008;6(3-4):191-201. Review.

2007

Lüke C, Dohmen C, Dietlein TS, Brunner R, Lüke M, Krieglstein GK. [High-dose intravenous immunoglobulins for treatment of optic neuritis in Guillain-Barré syndrome]. Klin Monbl Augenheilkd. 2007 Dec;224(12):932-4.

Weigelt K, Ernst W, Walczak Y, Ebert S, Loenhardt T, Klug M, Rehli M, Weber BH, Langmann T. Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation. J Leukoc Biol. 2007 Dec;82(6):1564-74.

Weisbach V, Dietrich T, Kruse FE, Eckstein R, Cursiefen C. HIV and hepatitis B/C infections in patients donating blood for use as autologous serum eye drops. Br J Ophthalmol. 2007 Dec;91(12):1724-5.

Foerster CG, Langenbucher A, Cursiefen C, Kruse FE, Seitz B. Delayed epithelial healing after keratoplasty for lattice corneal dystrophy. Cornea. 2007 Dec;26(10):1182-3.

Jacobi C, Wenkel H, Jacobi A, Korn K, Cursiefen C, Kruse FE. Hepatitis C and ocular surface disease. Am J Ophthalmol. 2007 Nov;144(5):705-711.

Heimerl S, Bosserhoff AK, Langmann T, Ecker J, Schmitz G. Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells. Melanoma Res. 2007 Oct;17(5):265-73.

Maier AK, Kociok N, Zahn G, Vossmeyer D, Stragies R, Muether PS, Joussen AM. Modulation of hypoxia-induced neovascularization by JSM6427, an integrin alpha5beta1 inhibiting molecule. Curr Eye Res. 2007 Sep;32(9):801-12.

Muether PS, Dell S, Kociok N, Zahn G, Stragies R, Vossmeyer D, Joussen AM. The role of integrin alpha5beta1 in the regulation of corneal neovascularization. Exp Eye Res. 2007 Sep;85(3):356-65.

Mietz H, Welsandt G, Hueber A, Esser C, Krieglstein GK. Synergistic effects of combined cytotoxic and apoptosis-inducing drugs on Tenon's capsule fibroblasts in vitro and in vivo. Graefes Arch Clin Exp Ophthalmol. 2007 Sep;245(9):1367-75.

Joussen AM, Kirchhof B, Schrage N, Ocklenburg C, Hilgers RD; HSO Study Group. Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): design issues and implications. Acta Ophthalmol Scand. 2007 Sep;85(6):623-30.

Wistuba W, Gnewuch C, Liebisch G, Schmitz G, Langmann T. Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR. World J Gastroenterol. 2007 Aug 21;13(31):4230-5.

Orsó E, Moehle C, Boettcher A, Szakszon K, Werner T, Langmann T, Liebisch G, Buechler C, Ritter M, Kronenberg F, Dieplinger H, Bornstein SR, Stremmel W, Schmitz G. The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases. Horm Metab Res. 2007 Aug;39(8):601-11.

Nguyen NX, Seitz B, Martus P, Langenbucher A, Cursiefen C. Long-term topical steroid treatment improves graft survival following normal-risk penetrating keratoplasty. Am J Ophthalmol.2007 Aug;144(2):318-9.

Dietrich T, Onderka J, Bock F, Kruse FE, Vossmeyer D, Stragies R, Zahn G, Cursiefen C. Inhibition of inflammatory lymphangiogenesis by integrin alpha5 blockade. Am J Pathol. 2007 Jul;171(1):361-72.

Schifferer R, Liebisch G, Bandulik S, Langmann T, Dada A, Schmitz G. ApoA-I induces a preferential efflux of monounsaturated phosphatidylcholine and medium chain sphingomyelin species from a cellular pool distinct from HDL(3) mediated phospholipid efflux. Biochim Biophys Acta. 2007 Jul;1771(7):853-63.

Kirchhof B, Bornfeld N, Grehn F. The delicate topic of the impact factor. Graefes Arch Clin Exp Ophthalmol.2007 Jul;245(7):925-7.

Dietlein TS, Jordan J, Krieglstein GK. [Lateral tube repositioning following a Baerveldt glaucoma implant. An alternative surgical procedure in the case of repeated conjunctival arrosion]. Ophthalmologe. 2007 Jun;104(6):508-10.

Joussen AM, Lehmacher W, Hilgers RD, Kirchhof B. Is significant relevant? Validity and patient benefit of randomized controlled clinical trials on age-related macular degeneration. Surv Ophthalmol. 2007 May-Jun;52(3):266-78. Review.

Langmann T. Microglia activation in retinal degeneration. J Leukoc Biol. 2007 Jun;81(6):1345-51. Epub 2007 Apr 3. Review.

Cursiefen C, Rummelt C, Beckmann MW, Kruse FE. Amniotic membrane-covered bio-onlays for treatment of ocular surface disease. Br J Ophthalmol. 2007 Jun;91(6):841-2.

Bock F, Onderka J, Dietrich T, Bachmann B, Kruse FE, Paschke M, Zahn G, Cursiefen C. Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2545-52.

Chen L, Hamrah P, Cursiefen C, Zhang Q, Pytowski B, Streilein JW, Dana MR. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. 2004. Ocul Immunol Inflamm. 2007 May-Jun;15(3):275-8.

Lappas A, Kirchhof B, Konen W. [Effects of the long-term tamponade with Densiron on the lens]. Klin Monbl Augenheilkd. 2007 May;224(5):434-7.

Pollhammer M, Meiller R, Rummelt C, Thyzel R, Cursiefen C, Kruse FE. In situ ablation of lens epithelial cells in porcine eyes with the laser photolysis system. J Cataract Refract Surg. 2007 Apr;33(4):697-701.

Bock F, König Y, Dietrich T, Zimmermann P, Baier M, Cursiefen C. [Inhibition of angiogenesis in the anterior chamber of the eye]. Ophthalmologe. 2007 Apr;104(4):336-44. Review.

Maaijwee KJ, van Meurs JC, Kirchhof B, Mooij CM, Fischer JH, Mackiewicz J, Kobuch K, Joussen AM. Histological evidence for revascularisation of an autologous retinal pigment epithelium--choroid graft in the pig. Br J Ophthalmol. 2007 Apr;91(4):546-50.

Mackiewicz J, Mühling B, Hiebl W, Meinert H, Maaijwee K, Kociok N, Lüke C, Zagorski Z, Kirchhof B, Joussen AM. In vivo retinal tolerance of various heavy silicone oils. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1873-83.

Zahn A, Moehle C, Langmann T, Ehehalt R, Autschbach F, Stremmel W, Schmitz G. Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis. World J Gastroenterol.2007 Mar 21;13(11):1687-95.

Nguyen NX, Pham HN, Langenbucher A, Cursiefen C, Seitz B. Impact of short-term versus longterm topical steroid treatment on 'idiopathic' endothelial cell loss after normal-risk penetrating keratoplasty. Acta Ophthalmol Scand. 2007 Mar;85(2):209-12.

Joussen AM, Joeres S, Fawzy N, Heussen FM, Llacer H, van Meurs JC, Kirchhof B. Autologous translocation of the choroid and retinal pigment epithelium in patients with geographic atrophy. Ophthalmology. 2007 Mar;114(3):551-60. PubMed PMID: 17324697.

Gehrig A, Langmann T, Horling F, Janssen A, Bonin M, Walter M, Poths S, Weber BH. Genome-wide expression profiling of the retinoschisin-deficient retina in early postnatal mouse development. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):891-900.

Lüke C, Lüke M, Aisenbrey S, Dietlein TS, Bartz-Schmidt KU, Kirchhof B, Walter P. [Changes of the triple flash electroretinogram after 360 degrees retinotomy and macular translocation for subfoveal choroidal neovascularisation in age-related macular degeneration]. Klin Monbl Augenheilkd. 2007 Feb;224(2):120-6.

Cursiefen C. Immune privilege and angiogenic privilege of the cornea. Chem Immunol Allergy. 2007;92:50-7. Review.

Nach oben scrollen