CIRCL

 

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About CIRCL
Team
Recent and ongoing studies

Services
Selected Publications


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Contact:


CIRCL – Cologne Image Reading Center and Laboratory
Center for Ophthalmology
University of Cologne
Kerpener Str. 62
50924 Cologne, Germany


About CIRCL:

The Cologne Image Reading Center and Laboratory (CIRCL) was established in 2008 under the direction of Sandra Liakopoulos, MD. Dr. Liakopoulos was trained in image analysis at the Doheny Image Reading Center (DIRC) in Los Angeles under the direction of SriniVas R. Sadda, MD, and served as a senior grader for the DIRC from June 2006 till June 2007.
The CIRCL provides qualitative and quantitative analysis of color fundus photography, fluorescein angiography, autofluorescence and optical coherence tomography (OCT) images in support of clinical research studies, with a focus on age-related macular degeneration, diabetic retinopathy and retinal vein occlusion. All images are graded according to the standard grading protocol of the CIRCL. Additional features or specific grading considerations may be defined in study specific grading protocols.
Among the goals of the Reading Center are the phenotyping for epidemiological studies, follow-up studies to demonstrate the safety and efficacy of potential new treatments and the validation of non-invasive imaging techniques in the monitoring and management of ophthalmic diseases.


 

CIRCL Team:

Reading Center Medical Director: Sandra Liakopoulos, MD 

liakopoulos_sandra.jpg

 

 

Study Coordinators:

Project Manager:

  • Sarah Hoenig
  • Maren Piel
  • Julia Stas
  • Sandra Liakopoulos, MD

 

Data Manager:

  • Burcu Basdinkci
  • Sarah Hoenig
  • Maren Piel
  • Julia Stas
  • Melanie Winnen

 

Grader:

  • Burcu Basdinkci
  • Lisa Engel, MD
  • Lebriz Ersoy, MD
  • Boris Hiltawsky
  • Sandra Liakopoulos, MD
  • Tina Schick, MD
  • Nikolaus Stas
  • Melanie Winnen

 

IT Support:

  • Dr. rer. Nat Herbert Kühner
  • UK-IT

Recent and ongoing studies and contact persons:

EUGENDA                           

European Genetic Database - www.eugenda.org

Collaboration with Radboud University Nijmegen Medical Centre

EUGENDA is a multicenter case-control study and was founded to find answers to important questions regarding the development and therapy of age-related macular degeneration collecting multimodal imaging, genetic data and diverse serum and plasma parameters.

Project Manager: Tina Schick ([Email protection active, please enable JavaScript.])

 

RELATION                           CRFB002DDE13

A 12-month, two-armed, randomized, double-masked, multicenter, Phase IIIb study assessing the efficacy and safety of laser photocoagulation as adjunctive to Ranibizumab intravitreal injections vs. laser photocoagulation monotherapy in patients with visual impairment due to diabetic macular edema followed by a 12 month follow up period.

Projekt Manager: Julia Stas ([Email protection active, please enable JavaScript.])

 

PRIDE                                   CRFB002DDE21

Multicenter randomized open-label three-arms controlled 12 months clinical proof of concept study to evaluate efficacy and safety of Ranibizumab alone or in combination with laser photocoagulation vs. laser photocoagulation alone in Proliferative Diabetic Retinopathy

Project Manager: Sarah Hoenig ([Email protection active, please enable JavaScript.])

 

OCEAN - ORCA Modul      CRFB002ADE18

Observation of treatment patterns with Lucentis in age-related macular degeneration, diabetic retinopathy and retinal vein occlusion in real life ophthalmic monitoring, including follow-up care with OCT

Collaboration with GRADE (Bonn) and M3 (Münster)

Projekt Manager: Sarah Hoenig ([Email protection active, please enable JavaScript.])

 

SALT                                    CRFB002ADE23

A 12-month, phase IV, randomized, open label, multicenter study to compare efficacy of 0.5 mg ranibizumab PRN versus 2 mg aflibercept bimonthly intravitreal injections on retinal thickness stability till month 6 of treatment and explore functional outcomes up to month 12 in patients with neovascular (wet) age-related macular degeneration (AMD)

Project Manager: Sandra Liakopoulos ([Email protection active, please enable JavaScript.])

 


 

Services:

Services provided by the CIRCL include:

  • Assistance with clinical protocol development, including reading center-related outcome parameters and inclusion / exclusion criteria
  • Development and provision of standardized photography protocols, certification and examination manuals
  • Certification of photographers for study-specific imaging
  • Data transfer: instruction for clinical sites in methods for documenting and transmitting images captured for the study
  • Data storage: secure long-term archival of study materials, both digital and hardcopy
  • Development of case report forms (CRFs)
  • Application of the standard grading protocol of the CIRCL, and development of study-specific grading procedures and protocols if necessary
  • Qualitative and quantitative assessment of color fundus photography (FP), fluorescein angiography (FA), autofluorescence (AF) and optical coherence tomography (OCT) images
  • Assessment of each image set by two trained, certified graders
  • Support, feedback and training for acquisition and transmission of imaging data to personnel that is involved in the study at each clinical site
  • Quality Assurance Procedures

 


 

Acknowledgement:

We would like to thank SriniVas R. Sadda, MD, and Alexander C. Walsh, MD from the Doheny Image Reading Center (DIRC), Keck school of Medicine of the University of Southern California, Los Angeles for their continued mentoring and support.
The standard grading protocol of the CIRCL was adopted from the DIRC grading protocol. The software used for image viewing and quantitative analysis of OCT images was developed and kindly provided by DIRC software engineers.

 


 

Selected Publications:

  1. Liakopoulos S, Keane PA, Ristau T, Kirchhof B, Walsh AC, Sadda SR.          Atypical outer retinal fluid accumulation in choroidal neovascularization: a novel OCT finding.                                                                                                      Ophthalmic Surg Lasers Imaging Retina. 2013 Nov-Dec;44(6 Suppl):S11-8. doi: 10.3928/23258160-20131101-03.
  2. Helgason H, Sulem P, Duvvari MR, Luo H, Thorleifsson G, Stefansson H, Jonsdottir I, Masson G, Gudbjartsson DF, Walters GB, Magnusson OT, Kong A, Rafnar T, Kiemeney LA, Schoenmaker-Koller FE, Zhao L, Boon CJ, Song Y, Fauser S, Pei M, Ristau T, Patel S, Liakopoulos S, van de Ven JP, Hoyng CB, Ferreyra H, Duan Y, Bernstein PS, Geirsdottir A, Helgadottir G, Stefansson E, den Hollander AI, Zhang K, Jonasson F, Sigurdsson H, Thorsteinsdottir U, Stefansson K.                                        A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration.                                                                                          Nat Genet. 2013 Nov;45(11):1371-4. doi: 10.1038/ng.2740. Epub 2013 Sep 15.
  3. Ziemssen F, Schmitz-Valckenberg S, Spital G, Liakopoulos S, Wiedon, Scheidl S, Holz FG.                                                                                                             ORCA: Evaluierung der SD-OCT Befundung in der täglichen Praxisroutine (B) 26. Internationaler Kongress der Deutschen Ophthalmochirurgen; 20130613-20130615; Nürnberg; DOCePO 3.2 /20131018/ Published: 2013 Oct 18; doi: 10.3205/13doc195.
  4. Ziemssen F, Wiedon A, Spital G, Schmitz-Valckenberg S, Scheidl S, Liakopoulos S, Holz FG, for the Ocean Investigators.                                                                               Ocean – Beobachtung von Therapieansätzen mit Lucentis im Praxisalltag.      DOG 2013 Sep, Do18-02.
  5. Ersoy L, Ristau T, Kirchhof B, Liakopoulos S.                                                        Response to anti-VEGF therapy in patients with subretinal fluid and pigment epithelial detachment on spectral-domain optical coherence tomography.                           Graefes Arch Clin Exp Ophthalmol. 2013 Nov 26. Epub ahead of print.
  6. Ristau T, HillebrandS, SmailhodzicS, UpdikeJ, WalshAC, KirchhofB, SaddaSR, LiakopoulosS.                                                                                                       SDOCT and angiography related prognostic factors for visual acuity outcome after ranibizumab in patients with neovascular AMD.                                         Clin and Exp Ophthalmology. 2013.
  7. Ristau T, Keane PA, Walsh AC, Engin A, Mokwa N, Kirchhof B, Sadda SR, Liakopoulos S.                                                                                                            Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration.                                                                                                 Ophthalmologica. 2014;231(1):37-44. doi: 10.1159/000354551. Epub 2013 Oct 2. 
  8. Lohmann CP, Voegeler J, Liakopoulos S, Wiedemann PM, Spital G, Lang GE.                                                                                                                                                                     Double-Masked Trial Demonstrates Superiority Of Combined Ranibizumab Plus Laser Versus Laser In Patients With Diabetic Macular Edema With Or Without Proliferative Diabetic Retinopathy                                                                                                           ARVO 2013, ABSTRACT FINAL ID: 1239.
  9. Ristau T, Voegeler J, Lang GE, Liakopoulos S.                                                                     Relevance of inner versus outer retinal thickness in diabetic macular edema in the RELATION study                                                                                                                ARVO 2013, ABSTRACT FINAL ID: 2376 - C0077.
  10. van de Ven JP, Nilsson SC, Tan PL, Buitendijk GH, Ristau T, Mohlin FC, Nabuurs SB, Schoenmaker-Koller FE, Smailhodzic D, Campochiaro PA, Zack DJ, Duvvari MR, Bakker B, Paun CC, Boon CJ, Uitterlinden AG, Liakopoulos S, Klevering BJ, Fauser S, Daha MR, Katsanis N, Klaver CC, Blom AM, Hoyng CB, den Hollander AI.
    A functional variant in the CFI gene confers a high risk of age-related macular degeneration.
    Nat Genet. 2013 Jul;45(7):813-7.
  11. Mokwa NF, Ristau T, Keane PA, Kirchhof B, Sadda SR, Liakopoulos S.
    Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography.
    J Ophthalmol. 2013;2013:385915.
  12. Keane PA, Patel PJ, Liakopoulos S, Heussen FM, Sadda SR, Tufail A.
    Evaluation of age-related macular degeneration with optical coherence tomography.
    Surv Ophthalmol. 2012 Sep;57(5):389-414.
  13. Mokwa NF, Ristau T, Hermann MM, Walsh AC, Updike J, Kirchhof B, Sadda SR, Liakopoulos S.                                                                                          Assessment of Retinal Thickness with and without Manual Determination of the Foveal Center on SDOCT Volume Scans                                                                                           ARVO 2012, ABASTRACT FINAL ID: 1031 - A433.
  14. Fauser S, Smailhodzic D, Caramoy A, van de Ven JP, Kirchhof B, Hoyng CB, Klevering BJ, Liakopoulos S, den Hollander AI.
    Evaluation of serum lipid concentrations and genetic variants at high-density lipoprotein metabolism loci and TIMP3 in age-related macular degeneration.
    Invest Ophthalmol Vis Sci. 2011 Jul 25;52(8):5525-8.
  15. Sadda SR, Liakopoulos S, Keane PA, Ongchin SC, Msutta S, Chang KT, Walsh AC.
    Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions.
    Graefes Arch Clin Exp Ophthalmol. 2010 Feb;248(2):175-84.
  16. Keane PA, Mand PS, Liakopoulos S, Walsh AC, Sadda SR.
    Accuracy of retinal thickness measurements obtained with Cirrus optical coherence tomography.
    Br J Ophthalmol. 2009 Nov;93(11):1461-7.
  17. Sadda SR, Liakopoulos S, Keane PA, Ongchin SC, Msutta S, Chang KT, Walsh AC.
    Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions.
    Graefes Arch Clin Exp Ophthalmol. 2010 Feb;248:175-84.
  18. Keane PA, Liakopoulos S, Jivrajka RV, Chang KT, Alasil T, Walsh AC, Sadda SR.
    Evaluation of Optical Coherence Tomography Central Retinal Thickness Parameters for use as Anatomic Outcomes in Clinical Trial for Neovascular Age-Related Macular Degeneration.
    Invest Ophthalmol Vis Sci. 2009 Jul;50:3378-85.
  19. Keane PA, Chang KT, Liakopoulos S, Jivrajka R, Walsh AC, Sadda SR.
    Effect of Ranibizumab Frequency on Neurosensory Retinal Volume in Neovascular Age-Related Macular Degeneration.
    Retina. 2009 May;29:592-600.
  20. Keane PA, Bhatti RA, Brubaker JW, Liakopoulos S, Sadda SR, Walsh AC. Comparison of Clinically Relevant Findings from High-Speed Fourier-Domain and Conventional Time-Domain Optical Coherence Tomography.
    Am J Ophthalmol. 2009 Aug;148:242-248.e1.
  21. Keane PA, Liakopoulos S, Chang KT, Wang M, Dustin L, Walsh AC, Sadda SR.
    Relationship between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration.
    Ophthalmology 2008 Dec 115:2206-14.
  22. Liakopoulos S, Ongchin S, Bansal A, Msutta S, Walsh AC, Updike PG, Sadda SR.
    Quantitative optical coherence tomography findings in various subtypes of neovascular age-related macular degeneration.
    Invest Ophthalmol Vis Sci. 2008 Nov;49:5048-54.
  23. Keane PA, Liakopoulos S, Chang KT, Heussen FM, Ongchin SC, Walsh AC, Sadda SR.
    Comparison of the optical coherence tomographic features of choroidal neovascular membranes in pathologic myopia versus age-related macular degeneration, using quantitative subanalysis.
    Br J Ophthalmol. 2008 Aug;92:1081-5.
  24. Keane PA, Liakopoulos S, Ongchin SC, Heussen FM, Msutta S, Chang KT, Walsh AC, Sadda SR.
    Quantitative Subanalysis of Optical Coherence Tomography after treatment with Ranibizumab for Neovascular Age-Related Macular Degeneration.
    Invest Ophthalmol Vis Sci. 2008 Jul;49:3115-20.
  25. Joeres S, Kaplowitz K, Brubaker JW, Updike PG, Collins AT, Walsh AC, Romano PW, Sadda SR.
    Quantitative Comparison of Optical Coherence Tomography after Pegaptanib or Bevacizumab in Neovascular Age-Related Macular Degeneration.
    Ophthalmology 2008 Feb;115:347-354.
  26. Joeres S, Tsong JW, Updike PG, Collins AT, Dustin L, Walsh AC, Romano PW, Sadda SR.
    Reproducibility of quantitative optical coherence tomography sub-analysis in neovascular age-related macular degeneration.
    Invest Ophthalmol Vis Sci. 2007 Sep;48:4300-7.
  27. Sadda SR, Joeres S, Wu Z, Updike PG, Romano P, Collins AT, Walsh AC.
    Error correction and quantitative sub-analysis of optical coherence tomography data using computer-assisted grading.
    Invest Ophthalmol Vis Sci. 2007 Feb;48:839-48.